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| As a series of operational protocols used for performing research, namely a cycle composed of theory, analytic or computational modelling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory. Since the objective is a model of the interactions in a system, the experimental techniques that most suit systems biology are those that are system-wide and attempt to be as complete as possible. Therefore, transcriptomics, metabolomics, proteomics and high-throughput techniques are used to collect quantitative data for the construction and validation of models. | | As a series of operational protocols used for performing research, namely a cycle composed of theory, analytic or computational modelling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory. Since the objective is a model of the interactions in a system, the experimental techniques that most suit systems biology are those that are system-wide and attempt to be as complete as possible. Therefore, transcriptomics, metabolomics, proteomics and high-throughput techniques are used to collect quantitative data for the construction and validation of models. |
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− | 作为一系列用于进行研究的操作方案,即一个由理论、分析或计算模型组成的循环,以提出关于生物系统的具体可检验的假设,实验验证,然后使用新获得的细胞或细胞过程的定量描述来精炼计算模型或理论。既然目标是一个系统中相互作用的模型,那么最适合系统生物学的实验技术就是那些全系统范围的、试图尽可能完整的实验技术。因此,转录组学、代谢组学、蛋白质组学和高通量技术被用来收集定量数据以用于模型的建立和验证。
| + | 系统生物学是一系列用于进行研究的操作方案,即一个由理论、分析或计算模型组成的循环,首先提出关于生物系统的具体可检验的假设,接着进行实验验证,然后使用新获得的细胞或细胞过程的定量描述来优化计算模型或理论。既然目标是一个系统中相互作用的模型,那么最适合系统生物学的实验技术就是那些全系统范围的、尽可能完整的实验技术。因此,转录组学、代谢组学、蛋白质组学和高通量技术被用来收集定量数据,从而用于模型的建立和验证。 |
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| As the application of dynamical systems theory to molecular biology. Indeed, the focus on the dynamics of the studied systems is the main conceptual difference between systems biology and bioinformatics. | | As the application of dynamical systems theory to molecular biology. Indeed, the focus on the dynamics of the studied systems is the main conceptual difference between systems biology and bioinformatics. |
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− | 作为动态系统理论在分子生物学中的应用。事实上,对所研究系统的动力学的关注是系统生物学和生物信息学之间的主要概念差异。
| + | 系统生物学是动力系统理论在分子生物学中的应用。事实上,对所研究系统的动力学的关注是系统生物学和生物信息学之间的主要概念差异。 |
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| As a socioscientific phenomenon defined by the strategy of pursuing integration of complex data about the interactions in biological systems from diverse experimental sources using interdisciplinary tools and personnel. | | As a socioscientific phenomenon defined by the strategy of pursuing integration of complex data about the interactions in biological systems from diverse experimental sources using interdisciplinary tools and personnel. |
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− | 作为一种社会科学现象,它的定义是利用跨学科的工具和人员,从不同的实验来源整合有关生物系统相互作用的复杂数据。
| + | 系统生物学也是一种社会科学现象,它利用跨学科的工具和人员,从不同的实验来源整合有关生物系统相互作用的复杂数据。 |
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| This variety of viewpoints is illustrative of the fact that systems biology refers to a cluster of peripherally overlapping concepts rather than a single well-delineated field. However, the term has widespread currency and popularity as of 2007, with chairs and institutes of systems biology proliferating worldwide. | | This variety of viewpoints is illustrative of the fact that systems biology refers to a cluster of peripherally overlapping concepts rather than a single well-delineated field. However, the term has widespread currency and popularity as of 2007, with chairs and institutes of systems biology proliferating worldwide. |
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− | 这种观点的多样性说明了这样一个事实,即系统生物学指的是一系列周边重叠的概念,而不是一个单一的界定清楚的领域。然而,随着系统生物学的教席和研究所在全球范围内的激增,这个术语在2007年已经广泛流行和普及。
| + | 各种各样的观点说明了这样一个事实,即系统生物学指的是一系列周边重叠概念的集合,而不是一个单独界定清楚的领域。然而,随着系统生物学的教职和研究机构在全球范围内的激增,这个术语在2007年已经广泛流行和普及。 |
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| == History == | | == History == |