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Oparin-Haldane猜想解决的是核酸聚合物和双螺旋的形成,而不是解离。然而,核酸是不寻常的,因为在没有反离子(低盐)中和对立的磷酸基团上的高电荷时,核酸双螺旋会解离成单链。<ref name="ReferenceB">{{Cite journal |doi = 10.1016/j.icarus.2003.10.018|title = Fast tidal cycling and the origin of life|year = 2004|last1 = Lathe|first1 = Richard|journal = Icarus|volume = 168|issue = 1|pages = 18–22|bibcode = 2004Icar..168...18L}}</ref>早期的潮汐,在近月的驱动下,可能产生了快速的稀释(高潮、低盐)和浓缩(低潮、高盐时干涸)循环,通过被称为潮汐链式反应(TCR)的过程,<ref>{{Cite journal |doi = 10.1017/S1473550405002314|title = Tidal chain reaction and the origin of replicating biopolymers|year = 2005|last1 = Lathe|first1 = Richard|journal = International Journal of Astrobiology|volume = 4|issue = 1|pages = 19–31|bibcode = 2005IJAsB...4...19L}}</ref>专门促进核酸<ref name="ReferenceB"/>的复制。 这一理论受到了批评,理由是早期的潮汐可能并不那么快,<ref>{{Cite journal |doi = 10.1016/j.icarus.2005.04.022|title = Comment on the paper "Fast tidal cycling and the origin of life" by Richard Lathe|year = 2006|last1 = Varga|first1 = P.|last2 = Rybicki|first2 = K.|last3 = Denis|first3 = C.|journal = Icarus|volume = 180|issue = 1|pages = 274–276|bibcode = 2006Icar..180..274V}}</ref>尽管从目前数值的回归需要在二十亿年左右的地月毗邻***,但没有证据表明这一点,而且早期的潮汐可能大约是每7个小时一次。<ref>{{Cite journal |doi = 10.1016/j.icarus.2005.08.019|title = Early tides: Response to Varga et al|year = 2006|last1 = Lathe|first1 = R.|journal = Icarus|volume = 180|issue = 1|pages = 277–280|bibcode = 2006Icar..180..277L}}</ref> 另一种批评认为,直到陆地演化的晚期,只有2-3%的地壳可能暴露在海面上。<ref>{{Cite journal | doi=10.1016/j.epsl.2008.08.029| title=A case for late-Archaean continental emergence from thermal evolution models and hypsometry| year=2008| last1=Flament| first1=Nicolas| last2=Coltice| first2=Nicolas| last3=Rey| first3=Patrice F.| journal=Earth and Planetary Science Letters| volume=275| issue=3–4| pages=326–336| bibcode=2008E&PSL.275..326F}}</ref>
 
Oparin-Haldane猜想解决的是核酸聚合物和双螺旋的形成,而不是解离。然而,核酸是不寻常的,因为在没有反离子(低盐)中和对立的磷酸基团上的高电荷时,核酸双螺旋会解离成单链。<ref name="ReferenceB">{{Cite journal |doi = 10.1016/j.icarus.2003.10.018|title = Fast tidal cycling and the origin of life|year = 2004|last1 = Lathe|first1 = Richard|journal = Icarus|volume = 168|issue = 1|pages = 18–22|bibcode = 2004Icar..168...18L}}</ref>早期的潮汐,在近月的驱动下,可能产生了快速的稀释(高潮、低盐)和浓缩(低潮、高盐时干涸)循环,通过被称为潮汐链式反应(TCR)的过程,<ref>{{Cite journal |doi = 10.1017/S1473550405002314|title = Tidal chain reaction and the origin of replicating biopolymers|year = 2005|last1 = Lathe|first1 = Richard|journal = International Journal of Astrobiology|volume = 4|issue = 1|pages = 19–31|bibcode = 2005IJAsB...4...19L}}</ref>专门促进核酸<ref name="ReferenceB"/>的复制。 这一理论受到了批评,理由是早期的潮汐可能并不那么快,<ref>{{Cite journal |doi = 10.1016/j.icarus.2005.04.022|title = Comment on the paper "Fast tidal cycling and the origin of life" by Richard Lathe|year = 2006|last1 = Varga|first1 = P.|last2 = Rybicki|first2 = K.|last3 = Denis|first3 = C.|journal = Icarus|volume = 180|issue = 1|pages = 274–276|bibcode = 2006Icar..180..274V}}</ref>尽管从目前数值的回归需要在二十亿年左右的地月毗邻***,但没有证据表明这一点,而且早期的潮汐可能大约是每7个小时一次。<ref>{{Cite journal |doi = 10.1016/j.icarus.2005.08.019|title = Early tides: Response to Varga et al|year = 2006|last1 = Lathe|first1 = R.|journal = Icarus|volume = 180|issue = 1|pages = 277–280|bibcode = 2006Icar..180..277L}}</ref> 另一种批评认为,直到陆地演化的晚期,只有2-3%的地壳可能暴露在海面上。<ref>{{Cite journal | doi=10.1016/j.epsl.2008.08.029| title=A case for late-Archaean continental emergence from thermal evolution models and hypsometry| year=2008| last1=Flament| first1=Nicolas| last2=Coltice| first2=Nicolas| last3=Rey| first3=Patrice F.| journal=Earth and Planetary Science Letters| volume=275| issue=3–4| pages=326–336| bibcode=2008E&PSL.275..326F}}</ref>
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在深海喷口, TCR (潮汐链式反应)理论与热联合/解离相比,在力学上具有优势,因为潮汐链式反应要求链的组装(模板驱动的聚合)发生在干涸阶段,即前体最集中的时候,而热循环则需要聚合发生在冷阶段,即链的组装速度最低,前体可能更稀薄的时候。
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在深海喷口, TCR (潮汐链式反应)理论与热联合/解离相比,在力学上具有优势,因为潮汐链式反应要求链的组装(模板驱动的聚合)发生在干涸阶段,即前体最集中的时候,而热循环则需要聚合发生在冷阶段,即链的组装速度最低,前体可能更稀薄的时候。
 
      
===第一个在热循环过程中凝结底物的蛋白质:热合成作用===
 
===第一个在热循环过程中凝结底物的蛋白质:热合成作用===
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