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Block randomization is commonly used in the experiment with a relatively big sampling size to avoid the imbalance allocation of samples with important characteristics. In certain fields with strict requests of randomization such as clinical trials, the allocation would be predictable when there is no blinding process for conductors and the block size is limited. The blocks permuted randomization in strata could possibly cause an imbalance of samples among strata as the number of strata increases and the sample size is limited, For instance, there is a possibility that no sample is found meeting the characteristic of certain strata.
 
Block randomization is commonly used in the experiment with a relatively big sampling size to avoid the imbalance allocation of samples with important characteristics. In certain fields with strict requests of randomization such as clinical trials, the allocation would be predictable when there is no blinding process for conductors and the block size is limited. The blocks permuted randomization in strata could possibly cause an imbalance of samples among strata as the number of strata increases and the sample size is limited, For instance, there is a possibility that no sample is found meeting the characteristic of certain strata.
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区块随机试验通常用于样本量较大的实验,以避免具有重要特征的样本分配不平衡。 在某些对随机试验有严格要求的领域,如临床试验,当没有对导体(conductors)进行盲法处理且区块块大小有限时,分配是可预测的。 分层中的块置换随机试验可能会随着分层数量的增加和样本量的限制而导致分层之间的样本不平衡,例如,有可能找不到符合某些分层特征的样本<ref>{{Cite book|title=Fundamentals of clinical trials|others=Friedman, Lawrence M., 1942-, Furberg, Curt,, DeMets, David L., 1944-, Reboussin, David,, Granger, Christopher B.|date=27 August 2015|isbn=978-3-319-18539-2|edition=Fifth|location=New York|oclc=919463985}}</ref>。
    
为了避免重要特征样本分配不平衡的问题,实验中常采用分块随机化的方法,采样规模较大。在某些严格要求随机化的领域,例如临床试验,当没有导体的盲法和块大小有限时,分配是可以预测的。随着地层数量的增加和样本容量的限制,地层中的块体随机化可能导致地层之间样本的不平衡,例如,有可能找不到符合特定地层特征的样本。
 
为了避免重要特征样本分配不平衡的问题,实验中常采用分块随机化的方法,采样规模较大。在某些严格要求随机化的领域,例如临床试验,当没有导体的盲法和块大小有限时,分配是可以预测的。随着地层数量的增加和样本容量的限制,地层中的块体随机化可能导致地层之间样本的不平衡,例如,有可能找不到符合特定地层特征的样本。
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