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== Sloppiness与Sloppy理论 ==
== Sloppiness与Sloppy理论 ==
sloppiness是多参数系统的中常见的一种特性。具有这种特性的模型的参数往往有很多个，但是模型的行为仅取决于少数几个参数或参数的线性组合，其它参数或参数 的线性组合对模型的影响微乎其微。sloppiness特性在系统生物学<ref name = “Gutenkunst et.al, 2007”>Sloppy models and parameter indeterminacy in systems biology: [http://arxiv.org/abs/q-bio/0701039 "Universally Sloppy Parameter Sensitivities in Systems Biology"], Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey, Kevin S. Brown, Christopher R. Myers, James P. Sethna, PLoS Comput Biol3(10) e189 (2007). ([http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030189 PLoS], [http://dx.doi.org/10.1371/journal.pcbi.0030189 doi:10.1371/journal.pcbi.0030189]), [https://sethna.lassp.cornell.edu/pubPDF/SloppyEverywhere.pdf pdf]). [Reviewed in [http://biomedicalcomputationreview.org/4/1/4.pdf NewsBytes] of [http://biomedicalcomputationreview.org/ Biomedical Computation Review] (Winter 07/08); rated "Exceptional" on Faculty of 1000]. </ref>
sloppiness是多参数系统的中常见的一种特性。具有这种特性的模型的参数往往有很多个，但是模型的行为仅取决于少数几个参数或参数的线性组合，其它参数或参数 的线性组合对模型的影响微乎其微。sloppiness特性在系统生物学<ref name = "Gutenkunst et.al, 2007”>Sloppy models and parameter indeterminacy in systems biology: [http://arxiv.org/abs/q-bio/0701039 "Universally Sloppy Parameter Sensitivities in Systems Biology"], Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey, Kevin S. Brown, Christopher R. Myers, James P. Sethna, PLoS Comput Biol3(10) e189 (2007). ([http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030189 PLoS], [http://dx.doi.org/10.1371/journal.pcbi.0030189 doi:10.1371/journal.pcbi.0030189]), [https://sethna.lassp.cornell.edu/pubPDF/SloppyEverywhere.pdf pdf]). [Reviewed in [http://biomedicalcomputationreview.org/4/1/4.pdf NewsBytes] of [http://biomedicalcomputationreview.org/ Biomedical Computation Review] (Winter 07/08); rated "Exceptional" on Faculty of 1000]. </ref>
<ref name = “Transtrum et.al, 2015”>Sloppiness, information geometry, and model reduction: [http://arxiv.org/abs/1501.07668 Perspective: Sloppiness and Emergent Theories in Physics, Biology, and Beyond], Mark K. Transtrum, Benjamin B. Machta, Kevin S. Brown, Bryan C. Daniels, Christopher R. Myers, and James P. Sethna, [http://scitation.aip.org/content/aip/journal/jcp/143/1/10.1063/1.4923066 J. Chem. Phys. '''143''', 010901 (2015)], </ref><ref name = “Manatee et.al, 2016”>[http://gutengroup.mcb.arizona.edu/wp-content/uploads/Mannakee2016.pdf Sloppiness and the Geometry of Parameter Space.] In: Geris, L., Gomez-Cabrero, D. (eds) Mannakee, B.K., Ragsdale, A.P., Transtrum, M.K., Gutenkunst, R.N. (2016).[http://dx.doi.org/10.1007/978-3-319-21296-8_11 Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials], vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_11 </ref>、物理学<ref>[https://sethna.lassp.cornell.edu/pubPDF/PC12.pdf "The Statistical Mechanics of Complex Signaling Networks: Nerve Growth Factor Signaling"], Kevin S. Brown, Colin C. Hill, Guillermo A. Calero, Christopher R. Myers, Kelvin H. Lee, James P. Sethna, and Richard A. Cerione, Physical Biology '''1''', 184-195 (2004), with [https://sethna.lassp.cornell.edu/pubPDF/PC12Supporting.pdf supplemental material]. </ref>和数学<ref name = “Brown & Sethna, 2003”> [https://sethna.lassp.cornell.edu/pubPDF/SloppyModelPRE.pdf “Statistical Mechanics Approaches to Models with Many Poorly Known Parameters"], Kevin S. Brown and James P. Sethna, Phys. Rev. E '''68''', 021904 (2003). </ref>系统中无处不在。
<ref name = “Transtrum et.al, 2015”>Sloppiness, information geometry, and model reduction: [http://arxiv.org/abs/1501.07668 Perspective: Sloppiness and Emergent Theories in Physics, Biology, and Beyond], Mark K. Transtrum, Benjamin B. Machta, Kevin S. Brown, Bryan C. Daniels, Christopher R. Myers, and James P. Sethna, [http://scitation.aip.org/content/aip/journal/jcp/143/1/10.1063/1.4923066 J. Chem. Phys. '''143''', 010901 (2015)], </ref><ref name = “Manatee et.al, 2016”>[http://gutengroup.mcb.arizona.edu/wp-content/uploads/Mannakee2016.pdf Sloppiness and the Geometry of Parameter Space.] In: Geris, L., Gomez-Cabrero, D. (eds) Mannakee, B.K., Ragsdale, A.P., Transtrum, M.K., Gutenkunst, R.N. (2016).[http://dx.doi.org/10.1007/978-3-319-21296-8_11 Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials], vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_11 </ref>、物理学<ref>[https://sethna.lassp.cornell.edu/pubPDF/PC12.pdf "The Statistical Mechanics of Complex Signaling Networks: Nerve Growth Factor Signaling"], Kevin S. Brown, Colin C. Hill, Guillermo A. Calero, Christopher R. Myers, Kelvin H. Lee, James P. Sethna, and Richard A. Cerione, Physical Biology '''1''', 184-195 (2004), with [https://sethna.lassp.cornell.edu/pubPDF/PC12Supporting.pdf supplemental material]. </ref>和数学<ref name = “Brown & Sethna, 2003”> [https://sethna.lassp.cornell.edu/pubPDF/SloppyModelPRE.pdf “Statistical Mechanics Approaches to Models with Many Poorly Known Parameters"], Kevin S. Brown and James P. Sethna, Phys. Rev. E '''68''', 021904 (2003). </ref>系统中无处不在。