更改

[[File:Signal transduction pathways.svg|280px|thumb|right|Overview of [[signal transduction]] pathways]]

[[File:Signal transduction pathways.svg|280px|thumb|right|Overview of [[signal transduction]] pathways]]

[信号转导通路]概览

[信号转导通路]概览

系统生物学方法经常涉及机制模型的发展，比如从动态系统的基本构件的定量特性重建动态系统<ref name="dibernardo03" /><ref name="dibernardo05" /><ref name="dynamicmodel" /><ref>{{cite journal|last1=Korkut|first1=A|last2=Wang|first2=W|last3=Demir|first3=E|last4=Aksoy|first4=BA|last5=Jing|first5=X|last6=Molinelli|first6=EJ|last7=Babur|first7=Ö|last8=Bemis|first8=DL|last9=Onur Sumer|first9=S|last10=Solit|first10=DB|last11=Pratilas|first11=CA|last12=Sander|first12=C|title=Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells.|journal=eLife|date=18 August 2015|volume=4|pmid=26284497|doi=10.7554/eLife.04640|pmc=4539601}}</ref> 。例如，一个细胞网络可以进行数学建模<ref name=":0">{{Cite journal|last=Gupta|first=Ankur|last2=Rawlings|first2=James B.|date=April 2014|title=Comparison of Parameter Estimation Methods in Stochastic Chemical Kinetic Models: Examples in Systems Biology|journal=AIChE Journal|volume=60|issue=4|pages=1253–1268|doi=10.1002/aic.14409|issn=0001-1541|pmc=4946376|pmid=27429455}}</ref>，使用的方法来自化学动力学和控制理论。由于细胞网络中参数、变量和约束的数量庞大，系统生物学经常使用数值和如流平衡分析的计算技术。<ref name=dynamicmodel>{{cite book|last1=Tavassoly|first1=Iman|title=Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells|date=2015|publisher=Springer International Publishing|isbn=978-3-319-14961-5|doi=10.1007/978-3-319-14962-2|series=Springer Theses}}</ref><ref name=":0" />

系统生物学方法经常涉及机制模型的发展，比如从动态系统的基本构件的定量特性重建动态系统<ref name="dibernardo03" /><ref name="dibernardo05" /><ref name="dynamicmodel" />。例如，一个细胞网络可以进行数学建模<ref name=":0">{{Cite journal|last=Gupta|first=Ankur|last2=Rawlings|first2=James B.|date=April 2014|title=Comparison of Parameter Estimation Methods in Stochastic Chemical Kinetic Models: Examples in Systems Biology|journal=AIChE Journal|volume=60|issue=4|pages=1253–1268|doi=10.1002/aic.14409|issn=0001-1541|pmc=4946376|pmid=27429455}}</ref>，使用的方法来自化学动力学和控制理论。由于细胞网络中参数、变量和约束的数量庞大，系统生物学经常使用数值和如流平衡分析的计算技术。<ref name=dynamicmodel>{{cite book|last1=Tavassoly|first1=Iman|title=Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells|date=2015|publisher=Springer International Publishing|isbn=978-3-319-14961-5|doi=10.1007/978-3-319-14962-2|series=Springer Theses}}</ref><ref name=":0" />

 

== 生物信息学和数据分析==

== 生物信息学和数据分析==