The formal study of systems biology, as a distinct discipline, was launched by systems theorist [[Mihajlo Mesarovic]] in 1966 with an international symposium at the [[Case Western Reserve University|Case Institute of Technology]] in [[Cleveland]], [[Ohio]], titled "Systems Theory and Biology".<ref name="mesarovic68" /><ref name="science68" /> | The formal study of systems biology, as a distinct discipline, was launched by systems theorist [[Mihajlo Mesarovic]] in 1966 with an international symposium at the [[Case Western Reserve University|Case Institute of Technology]] in [[Cleveland]], [[Ohio]], titled "Systems Theory and Biology".<ref name="mesarovic68" /><ref name="science68" /> |