7,129
个编辑
更改
无编辑摘要
'''脑深部电刺激 Deep brain stimulation''' ('''DBS''')是神经外科手术中的操作之一，包括放置一种叫做神经刺激器的医疗设备，通过植入的电极将电脉冲发送到大脑中的特定目标(脑核) ，治疗包括帕金森病、原发性震颤、肌张力障碍<ref name=Kringelbach>{{cite journal|vauthors = Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ|title = Translational principles of deep brain stimulation|journal = Nature Reviews. Neuroscience|volume = 8|issue = 8 |pages = 623–35 |date = August 2007|pmid = 17637800|doi = 10.1038/nrn2196|s2cid = 147427108}}</ref>和其他疾病，如强迫症(OCD)和癫痫，引起的运动障碍。虽然其基本原理和机制尚不完全清楚，DBS 是一种可控的直接改变大脑活动的方式<ref name=Hammond>{{cite journal|vauthors = Hammond C, Ammari R, Bioulac B, Garcia L|s2cid = 14905206|title = Latest view on the mechanism of action of deep brain stimulation|journal = Movement Disorders|volume = 23|issue = 15|pages = 2111–21|date = November 2008|pmid = 18785230|doi = 10.1002/mds.22120|url = https://www.hal.inserm.fr/inserm-02950812/file/hammond%20mov%20disord-2.Envoy%C3%A902.01.08.pdf}}</ref><ref name=garcia>{{cite journal|vauthors = García MR, Pearlmutter BA, Wellstead PE, Middleton RH|title = A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation|journal = PLOS ONE|volume = 8|issue = 9|pages = e73456|year = 2013|pmid = 24066049|pmc = 3774723|doi = 10.1371/journal.pone.0073456|bibcode = 2013PLoSO...873456G|doi-access = free}}</ref>。
'''脑深部电刺激 Deep brain stimulation''' ('''DBS''')是神经外科手术中的操作之一，包括放置一种叫做'''神经刺激器 neurostimulator'''的医疗设备，通过植入的电极将电脉冲发送到大脑中的特定目标(脑核) ，治疗包括帕金森病、原发性震颤、肌张力障碍'''<ref name=Kringelbach>{{cite journal|vauthors = Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ|title = Translational principles of deep brain stimulation|journal = Nature Reviews. Neuroscience|volume = 8|issue = 8 |pages = 623–35 |date = August 2007|pmid = 17637800|doi = 10.1038/nrn2196|s2cid = 147427108}}</ref>和其他疾病，如强迫症(OCD)和癫痫，引起的运动障碍。虽然其基本原理和机制尚不完全清楚，DBS 是一种可控的直接改变大脑活动的方式<ref name=Hammond>{{cite journal|vauthors = Hammond C, Ammari R, Bioulac B, Garcia L|s2cid = 14905206|title = Latest view on the mechanism of action of deep brain stimulation|journal = Movement Disorders|volume = 23|issue = 15|pages = 2111–21|date = November 2008|pmid = 18785230|doi = 10.1002/mds.22120|url = https://www.hal.inserm.fr/inserm-02950812/file/hammond%20mov%20disord-2.Envoy%C3%A902.01.08.pdf}}</ref><ref name=garcia>{{cite journal|vauthors = García MR, Pearlmutter BA, Wellstead PE, Middleton RH|title = A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation|journal = PLOS ONE|volume = 8|issue = 9|pages = e73456|year = 2013|pmid = 24066049|pmc = 3774723|doi = 10.1371/journal.pone.0073456|bibcode = 2013PLoSO...873456G|doi-access = free}}</ref>。
== 医疗用途 ==
== 医疗用途 ==
[[Image:Parkinson surgery.jpg|thumb|250px|Insertion of electrode during surgery using a [[Stereotactic surgery|stereotactic frame]]]]
[[Image:Parkinson surgery.jpg|thumb|250px|在手术过程中使用立体定向框架插入电极]]
=== 帕金森氏病 ===
=== 帕金森氏病 ===
=== 重度抑郁症和强迫症 ===
=== 重度抑郁症和强迫症 ===
[[File:X-ray of deep brain stimulation in OCD, L.png|thumb|Lateral X-ray of the head: Deep brain stimulation in [[Obsessive–compulsive disorder]] (OCD). 42 year old man, surgery in 2013.]]
[[File:X-ray of deep brain stimulation in OCD, L.png|thumb|头部侧面 X 光片：强迫症(OCD) 中的深部脑刺激。42岁男性，2013年手术。]]
DBS已在少量临床试验中用于治疗严重难治性抑郁症(TRD)患者<ref name="Anderson">{{cite journal|vauthors = Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray JA, Berk M, Tye SJ|title = Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action|journal = Neuroscience and Biobehavioral Reviews|volume = 36|issue = 8|pages = 1920–33|date = September 2012|pmid = 22721950|doi = 10.1016/j.neubiorev.2012.06.001|s2cid = 207089716}}</ref>。DBS治疗TRD的神经解剖学靶点包括膝下扣带回、后直回<ref name=":24">{{cite journal|vauthors = Accolla EA, Aust S, Merkl A, Schneider GH, Kühn AA, Bajbouj M, Draganski B|title = Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression|journal = Journal of Affective Disorders|volume = 194|pages = 33–37|date = April 2016|pmid = 26802505|doi = 10.1016/j.jad.2016.01.022|doi-access = free}}</ref>、伏隔核<ref name=":25">{{cite journal|vauthors = Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V|title = Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression|journal = Neuropsychopharmacology|volume = 33|issue = 2|pages = 368–77|date = January 2008|pmid = 17429407|doi = 10.1038/sj.npp.1301408|doi-access = free}}</ref>、腹侧囊/腹侧纹状体、丘脑下蒂和外侧缰状核<ref name="Anderson" /> 。最近提出的DBS干预抑郁症的靶点是内侧前脑束的上外侧支;它的刺激导致惊人的快速抗抑郁作用<ref name=":26">{{cite journal|vauthors = Schlaepfer TE, Bewernick BH, Kayser S, Mädler B, Coenen VA|title = Rapid effects of deep brain stimulation for treatment-resistant major depression|journal = Biological Psychiatry|volume = 73|issue = 12|pages = 1204–12|date = June 2013|pmid = 23562618|doi = 10.1016/j.biopsych.2013.01.034|s2cid = 6374368}}</ref>。
DBS已在少量临床试验中用于治疗严重难治性抑郁症(TRD)患者<ref name="Anderson">{{cite journal|vauthors = Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray JA, Berk M, Tye SJ|title = Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action|journal = Neuroscience and Biobehavioral Reviews|volume = 36|issue = 8|pages = 1920–33|date = September 2012|pmid = 22721950|doi = 10.1016/j.neubiorev.2012.06.001|s2cid = 207089716}}</ref>。DBS治疗TRD的神经解剖学靶点包括膝下扣带回、后直回<ref name=":24">{{cite journal|vauthors = Accolla EA, Aust S, Merkl A, Schneider GH, Kühn AA, Bajbouj M, Draganski B|title = Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression|journal = Journal of Affective Disorders|volume = 194|pages = 33–37|date = April 2016|pmid = 26802505|doi = 10.1016/j.jad.2016.01.022|doi-access = free}}</ref>、伏隔核<ref name=":25">{{cite journal|vauthors = Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V|title = Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression|journal = Neuropsychopharmacology|volume = 33|issue = 2|pages = 368–77|date = January 2008|pmid = 17429407|doi = 10.1038/sj.npp.1301408|doi-access = free}}</ref>、腹侧囊/腹侧纹状体、丘脑下蒂和外侧缰状核<ref name="Anderson" /> 。最近提出的DBS干预抑郁症的靶点是内侧前脑束的上外侧支;它的刺激导致惊人的快速抗抑郁作用<ref name=":26">{{cite journal|vauthors = Schlaepfer TE, Bewernick BH, Kayser S, Mädler B, Coenen VA|title = Rapid effects of deep brain stimulation for treatment-resistant major depression|journal = Biological Psychiatry|volume = 73|issue = 12|pages = 1204–12|date = June 2013|pmid = 23562618|doi = 10.1016/j.biopsych.2013.01.034|s2cid = 6374368}}</ref>。
* 人脑映射组织
* 人脑映射组织
* 响应性神经刺激疗法设备
* 响应性神经刺激疗法设备
== 参考文献 ==
== 参考文献 ==
* [https://www.mountsinai.org/locations/center-neuromodulation/what-is/dbs/info 脑深部电刺激治疗运动障碍、强迫症、抽动秽语综合症或抑郁症中心]
* [https://www.mountsinai.org/locations/center-neuromodulation/what-is/dbs/info 脑深部电刺激治疗运动障碍、强迫症、抽动秽语综合症或抑郁症中心]
* [https://www.mountsinai.org/care/behavioral-health/services/ocd-tics/dbs 脑深部电刺激治疗强迫症中心]
* [https://www.mountsinai.org/care/behavioral-health/services/ocd-tics/dbs 脑深部电刺激治疗强迫症中心]
==编者推荐==
----
----
本中文词条神经动力学读书会词条梳理志愿者苏苏Anny翻译审校，[[用户:薄荷|薄荷]]编辑，如有问题，欢迎在讨论页面留言。