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Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted molecules that act as mediators; failure of key feedback mechanisms in cancer disrupts tissue function.<ref>{{cite journal|last1=Vlahopoulos|first1=SA|last2=Cen|first2=O|last3=Hengen|first3=N|last4=Agan|first4=J|last5=Moschovi|first5=M|last6=Critselis|first6=E|last7=Adamaki|first7=M|last8=Bacopoulou|first8=F|last9=Copland|first9=JA|last10=Boldogh|first10=I|last11=Karin|first11=M|last12=Chrousos|first12=GP|title=Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment.|journal=Cytokine & Growth Factor Reviews|date=20 June 2015|pmid=26119834|doi=10.1016/j.cytogfr.2015.06.001|volume=26|issue=4|pages=389–403|pmc=4526340}}</ref>
Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted molecules that act as mediators; failure of key feedback mechanisms in cancer disrupts tissue function.<ref>{{cite journal|last1=Vlahopoulos|first1=SA|last2=Cen|first2=O|last3=Hengen|first3=N|last4=Agan|first4=J|last5=Moschovi|first5=M|last6=Critselis|first6=E|last7=Adamaki|first7=M|last8=Bacopoulou|first8=F|last9=Copland|first9=JA|last10=Boldogh|first10=I|last11=Karin|first11=M|last12=Chrousos|first12=GP|title=Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment.|journal=Cytokine & Growth Factor Reviews|date=20 June 2015|pmid=26119834|doi=10.1016/j.cytogfr.2015.06.001|volume=26|issue=4|pages=389–403|pmc=4526340}}</ref>
正常组织的完整性是通过粘附分子和分泌分子作为介质介导的不同细胞类型之间的反馈相互作用来维护的；癌症中关键反馈机制的失效会破坏组织功能。
The loud squeals that sometimes occurs in audio systems, PA systems, and rock music are known as audio feedback. If a microphone is in front of a loudspeaker that it is connected to, sound that the microphone picks up comes out of the speaker, and is picked up by the microphone and re-amplified. If the loop gain is sufficient, howling or squealing at the maximum power of the amplifier is possible.
The loud squeals that sometimes occurs in audio systems, PA systems, and rock music are known as audio feedback. If a microphone is in front of a loudspeaker that it is connected to, sound that the microphone picks up comes out of the speaker, and is picked up by the microphone and re-amplified. If the loop gain is sufficient, howling or squealing at the maximum power of the amplifier is possible.