One approach to modeling the neurophysiology and the functioning of working memory is [[PBWM|prefrontal cortex basal ganglia working memory (PBWM)]]. In this model, the prefrontal cortex works hand-in-hand with the basal ganglia to accomplish the tasks of working memory. Many studies have shown this to be the case.<ref>{{Cite journal|last1=Baier|first1=B.|last2=Karnath|first2=H.-O.|last3=Dieterich|first3=M.|last4=Birklein|first4=F.|last5=Heinze|first5=C.|last6=Muller|first6=N. G.|date=2010-07-21|title=Keeping Memory Clear and Stable--The Contribution of Human Basal Ganglia and Prefrontal Cortex to Working Memory|journal=Journal of Neuroscience|volume=30|issue=29|pages=9788–9792|doi=10.1523/jneurosci.1513-10.2010|pmid=20660261|pmc=6632833|issn=0270-6474|doi-access=free}}</ref> One used ablation techniques in patients who had suffered from seizures and had damage to the prefrontal cortex and basal ganglia.<ref name=":2" /> Researchers found that such damage resulted in decreased capacity to carry out the executive function of working memory.<ref name=":2">{{Cite journal|last1=Voytek|first1=B.|last2=Knight|first2=R. T.|date=2010-10-04|title=Prefrontal cortex and basal ganglia contributions to visual working memory|journal=Proceedings of the National Academy of Sciences|volume=107|issue=42|pages=18167–18172|doi=10.1073/pnas.1007277107|pmid=20921401|issn=0027-8424|doi-access=free}}</ref> Additional research conducted on patients with brain alterations due to methamphetamine use found that training working memory increases volume in the basal ganglia.<ref>{{Cite journal|last1=Brooks|first1=S. J.|last2=Burch|first2=K. H.|last3=Maiorana|first3=S. A.|last4=Cocolas|first4=E.|last5=Schioth|first5=H. B.|last6=Nilsson|first6=E. K.|last7=Kamaloodien|first7=K.|last8=Stein|first8=D. J.|date=2016-02-01|title=Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use|url=http://www.sciencedirect.com/science/article/pii/S2213158216301541|journal=NeuroImage: Clinical|language=en|volume=12|pages=478–491|doi=10.1016/j.nicl.2016.08.019|pmid=27625988|issn=2213-1582|doi-access=free}}</ref> | One approach to modeling the neurophysiology and the functioning of working memory is [[PBWM|prefrontal cortex basal ganglia working memory (PBWM)]]. In this model, the prefrontal cortex works hand-in-hand with the basal ganglia to accomplish the tasks of working memory. Many studies have shown this to be the case.<ref>{{Cite journal|last1=Baier|first1=B.|last2=Karnath|first2=H.-O.|last3=Dieterich|first3=M.|last4=Birklein|first4=F.|last5=Heinze|first5=C.|last6=Muller|first6=N. G.|date=2010-07-21|title=Keeping Memory Clear and Stable--The Contribution of Human Basal Ganglia and Prefrontal Cortex to Working Memory|journal=Journal of Neuroscience|volume=30|issue=29|pages=9788–9792|doi=10.1523/jneurosci.1513-10.2010|pmid=20660261|pmc=6632833|issn=0270-6474|doi-access=free}}</ref> One used ablation techniques in patients who had suffered from seizures and had damage to the prefrontal cortex and basal ganglia.<ref name=":2" /> Researchers found that such damage resulted in decreased capacity to carry out the executive function of working memory.<ref name=":2">{{Cite journal|last1=Voytek|first1=B.|last2=Knight|first2=R. T.|date=2010-10-04|title=Prefrontal cortex and basal ganglia contributions to visual working memory|journal=Proceedings of the National Academy of Sciences|volume=107|issue=42|pages=18167–18172|doi=10.1073/pnas.1007277107|pmid=20921401|issn=0027-8424|doi-access=free}}</ref> Additional research conducted on patients with brain alterations due to methamphetamine use found that training working memory increases volume in the basal ganglia.<ref>{{Cite journal|last1=Brooks|first1=S. J.|last2=Burch|first2=K. H.|last3=Maiorana|first3=S. A.|last4=Cocolas|first4=E.|last5=Schioth|first5=H. B.|last6=Nilsson|first6=E. K.|last7=Kamaloodien|first7=K.|last8=Stein|first8=D. J.|date=2016-02-01|title=Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use|url=http://www.sciencedirect.com/science/article/pii/S2213158216301541|journal=NeuroImage: Clinical|language=en|volume=12|pages=478–491|doi=10.1016/j.nicl.2016.08.019|pmid=27625988|issn=2213-1582|doi-access=free}}</ref> |