As a series of operational [[protocol (natural sciences)|protocol]]s used for performing research, namely a cycle composed of theory, [[Mathematical model|analytic]] or [[computational model]]ling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.<ref name="kholodenko05" /> Since the objective is a model of the interactions in a system, the experimental techniques that most suit systems biology are those that are system-wide and attempt to be as complete as possible. Therefore, [[transcriptomics]], [[metabolomics]], [[proteomics]] and [[High-throughput screening|high-throughput techniques]] are used to collect quantitative data for the construction and validation of models.<ref name=Romualdi09 /> | As a series of operational [[protocol (natural sciences)|protocol]]s used for performing research, namely a cycle composed of theory, [[Mathematical model|analytic]] or [[computational model]]ling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.<ref name="kholodenko05" /> Since the objective is a model of the interactions in a system, the experimental techniques that most suit systems biology are those that are system-wide and attempt to be as complete as possible. Therefore, [[transcriptomics]], [[metabolomics]], [[proteomics]] and [[High-throughput screening|high-throughput techniques]] are used to collect quantitative data for the construction and validation of models.<ref name=Romualdi09 /> |