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[[File:SystemsBiologyTrendsInMostCitedResearch.png|thumb|不同时间维度生物学论文中被引用频率前30的文章里各个主题的占比，显示了系统生物学研究的趋势<ref>{{Cite journal|last1=Zou|first1=Yawen|last2=Laubichler|first2=Manfred D.|date=2018-07-25|title=From systems to biology: A computational analysis of the research articles on systems biology from 1992 to 2013|journal=PLOS ONE|language=en|volume=13|issue=7|pages=e0200929|doi=10.1371/journal.pone.0200929|issn=1932-6203|pmc=6059489|pmid=30044828|bibcode=2018PLoSO..1300929Z}}</ref>]]

[[File:SystemsBiologyTrendsInMostCitedResearch.png|thumb|不同时间维度生物学论文中被引用频率前30的文章里各个主题的占比，显示了系统生物学研究的趋势<ref>{{Cite journal|last1=Zou|first1=Yawen|last2=Laubichler|first2=Manfred D.|date=2018-07-25|title=From systems to biology: A computational analysis of the research articles on systems biology from 1992 to 2013|journal=PLOS ONE|language=en|volume=13|issue=7|pages=e0200929|doi=10.1371/journal.pone.0200929|issn=1932-6203|pmc=6059489|pmid=30044828|bibcode=2018PLoSO..1300929Z}}</ref>]]

然而，20世纪90年代功能基因组学的诞生意味着人们可以得到大量高质量的数据，同时计算能力爆炸式增长，使得更真实的模型成为可能。1992年至1994年，曾斌撰写系列关于系统医学、系统遗传学和系统生物工程方面的文章<ref>B.&nbsp;J. Zeng, "On the holographic model of human body", 1st National Conference of Comparative

然而，20世纪90年代功能基因组学的诞生意味着人们可以得到大量高质量的数据，同时计算能力爆炸式增长，使得更真实的模型成为可能。1992年至1994年，曾邦哲发表系列关于系统医学、系统遗传学和系统生物工程方面的文章<ref>B.&nbsp;J. Zeng, "On the holographic model of human body", 1st National Conference of Comparative

Studies Traditional Chinese Medicine and West Medicine, Medicine and Philosophy, April 1992 ("systems medicine and pharmacology" termed).</ref><ref>Zeng (B.) J., On the concept of system biological engineering, Communication on Transgenic Animals, No. 6, June, 1994.</ref><ref>B.&nbsp;J. Zeng, "Transgenic animal expression system – transgenic egg plan (goldegg plan)",

Studies Traditional Chinese Medicine and West Medicine, Medicine and Philosophy, April 1992 ("systems medicine and pharmacology" termed).</ref><ref>Zeng (B.) J., On the concept of system biological engineering, Communication on Transgenic Animals, No. 6, June, 1994.</ref><ref>B.&nbsp;J. Zeng, "Transgenic animal expression system – transgenic egg plan (goldegg plan)",

''Communication on Transgenic Animal'', Vol.1, No.11, 1994 (on the concept of system genetics and term coined).</ref><ref>B.&nbsp;J. Zeng, "From positive to synthetic science", ''Communication on Transgenic Animals'', No. 11, 1995 (on systems medicine).</ref><ref>B.&nbsp;J. Zeng, "The structure theory of self-organization systems", ''Communication on Transgenic Animals'',

''Communication on Transgenic Animal'', Vol.1, No.11, 1994 (on the concept of system genetics and term coined).</ref><ref>B.&nbsp;J. Zeng, "From positive to synthetic science", ''Communication on Transgenic Animals'', No. 11, 1995 (on systems medicine).</ref><ref>B.&nbsp;J. Zeng, "The structure theory of self-organization systems", ''Communication on Transgenic Animals'',

No.8-10, 1996. Etc.</ref><ref name="tomita97">B. J. Zeng, "The structure theory of self-organization systems", Communication on Transgenic Animals, No.8-10, 1996. Etc.</ref>，1996年，他在北京举行的第一届国际转基因动物会议上作了关于生物系统理论和系统方法研究的演讲。1997年，富田正丸小组发表了第一个关于整个（假设的）细胞新陈代谢的定量模型。

No.8-10, 1996. Etc.</ref><ref name="tomita97">B. J. Zeng, "The structure theory of self-organization systems", Communication on Transgenic Animals, No.8-10, 1996. Etc.</ref>，1996年，他在北京举行的第一届国际转基因动物学术研讨会议上作了关于生物系统理论和系统方法研究的演讲。1997年，富田正丸小组发表了第一个关于整个（假设的）细胞新陈代谢的定量模型。