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== Sloppiness与Sloppy理论 ==

== Sloppiness与Sloppy理论 ==

sloppiness是多参数系统的中常见的一种特性。具有这种特性的模型的参数往往有很多个，但是模型的行为仅取决于少数几个参数或参数的线性组合，其它参数或参数 的线性组合对模型的影响微乎其微。sloppiness特性在系统生物学<ref name = “Gutenkunst et.al, 2007”>Sloppy models and parameter indeterminacy in systems biology: "Universally Sloppy Parameter Sensitivities in Systems Biology", Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey, Kevin S. Brown, Christopher R. Myers, James P. Sethna, PLoS Comput Biol3(10) e189 (2007). (PLoS, doi:10.1371/journal.pcbi.0030189), pdf). [Reviewed in NewsBytes of Biomedical Computation Review (Winter 07/08); rated "Exceptional" on Faculty of 1000]. </ref>

sloppiness是多参数系统的中常见的一种特性。具有这种特性的模型的参数往往有很多个，但是模型的行为仅取决于少数几个参数或参数的线性组合，其它参数或参数 的线性组合对模型的影响微乎其微。sloppiness特性在系统生物学<ref name = “Gutenkunst et.al, 2007”>Sloppy models and parameter indeterminacy in systems biology: "Universally Sloppy Parameter Sensitivities in Systems Biology", Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey, Kevin S. Brown, Christopher R. Myers, James P. Sethna, PLoS Comput Biol3(10) e189 (2007). (PLoS, doi:10.1371/journal.pcbi.0030189), pdf). [Reviewed in NewsBytes of Biomedical Computation Review (Winter 07/08); rated "Exceptional" on Faculty of 1000]. </ref>

<ref name = “Transtrum et.al, 2015”>Sloppiness, information geometry, and model reduction: Perspective: Sloppiness and Emergent Theories in Physics, Biology, and Beyond, Mark K. Transtrum, Benjamin B. Machta, Kevin S. Brown, Bryan C. Daniels, Christopher R. Myers, and James P. Sethna, J. Chem. Phys. 143, 010901 (2015), </ref><ref name = “Manatee et.al, 2016”>Mannakee, B.K., Ragsdale, A.P., Transtrum, M.K., Gutenkunst, R.N. (2016). Sloppiness and the Geometry of Parameter Space. In: Geris, L., Gomez-Cabrero, D. (eds) Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_11 </ref>、物理学<ref name = “Brown et.al, 2004”>”The Statistical Mechanics of Complex Signaling Networks: Nerve Growth Factor Signaling", Kevin S. Brown, Colin C. Hill, Guillermo A. Calero, Christopher R. Myers, Kelvin H. Lee, James P. Sethna, and Richard A. Cerione, Physical Biology 1, 184-195 (2004), with supplemental material. </ref>和数学<ref name = “Brown & Sethna, 2003”> “Statistical Mechanics Approaches to Models with Many Poorly Known Parameters", Kevin S. Brown and James P. Sethna, Phys. Rev. E 68, 021904 (2003). </ref>系统中无处不在。

<ref name = “Transtrum et.al, 2015”>Sloppiness, information geometry, and model reduction: Perspective: Sloppiness and Emergent Theories in Physics, Biology, and Beyond, Mark K. Transtrum, Benjamin B. Machta, Kevin S. Brown, Bryan C. Daniels, Christopher R. Myers, and James P. Sethna, J. Chem. Phys. 143, 010901 (2015), </ref><ref name = “Manatee et.al, 2016”>Mannakee, B.K., Ragsdale, A.P., Transtrum, M.K., Gutenkunst, R.N. (2016). Sloppiness and the Geometry of Parameter Space. In: Geris, L., Gomez-Cabrero, D. (eds) Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_11 </ref>、物理学<ref>”The Statistical Mechanics of Complex Signaling Networks: Nerve Growth Factor Signaling", Kevin S. Brown, Colin C. Hill, Guillermo A. Calero, Christopher R. Myers, Kelvin H. Lee, James P. Sethna, and Richard A. Cerione, Physical Biology 1, 184-195 (2004), with supplemental material. </ref>和数学<ref name = “Brown & Sethna, 2003”> “Statistical Mechanics Approaches to Models with Many Poorly Known Parameters", Kevin S. Brown and James P. Sethna, Phys. Rev. E 68, 021904 (2003). </ref>系统中无处不在。