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→Activity motifs
这种类型的网络存在于多个调节子结合起来控制一组基因的情形，并且有多种调控的组合。这种模体出现在[[大肠杆菌]]的多种系统中，例如碳利用、厌氧生长、应激反应等。<ref name="she1"/><ref name="boy1"/> 为了更好地理解这种网络，我们必须得到关于基因集成多种输入的方式的信息。Kaplan ''et al.''<ref name="kap2">{{cite journal |vauthors=Kaplan S, Bren A, Zaslaver A, Dekel E, Alon U |title=Diverse two-dimensional input functions control bacterial sugar genes |journal=Mol. Cell |volume=29 |issue=6 |pages=786–92 |date=March 2008 |pmid=18374652 |pmc=2366073 |doi=10.1016/j.molcel.2008.01.021 }}</ref>绘制了[[大肠杆菌]]糖利用基因的输入函数，表现出各种各样的形状。
这种类型的网络存在于多个调节子结合起来控制一组基因的情形，并且有多种调控的组合。这种模体出现在[[大肠杆菌]]的多种系统中，例如碳利用、厌氧生长、应激反应等。<ref name="she1"/><ref name="boy1"/> 为了更好地理解这种网络，我们必须得到关于基因集成多种输入的方式的信息。Kaplan ''et al.''<ref name="kap2">{{cite journal |vauthors=Kaplan S, Bren A, Zaslaver A, Dekel E, Alon U |title=Diverse two-dimensional input functions control bacterial sugar genes |journal=Mol. Cell |volume=29 |issue=6 |pages=786–92 |date=March 2008 |pmid=18374652 |pmc=2366073 |doi=10.1016/j.molcel.2008.01.021 }}</ref>绘制了[[大肠杆菌]]糖利用基因的输入函数，表现出各种各样的形状。
==Activity motifs==
==活动模体/Activity motifs==
An interesting generalization of the network-motifs, '''activity motifs''' are over occurring patterns that can be found when nodes and edges in the network are annotated with quantitative features. For instance, when edges in a metabolic pathways are annotated with the magnitude or timing of the corresponding gene expression, some patterns are over occurring '''given''' the underlying network structure.<ref name="agc">{{cite journal |vauthors=Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D |title=Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network |journal=Nat. Biotechnol. |volume=26 |issue=11 |pages=1251–9 |date=November 2008 |pmid=18953355 |pmc=2651818 |doi=10.1038/nbt.1499}}</ref>
An interesting generalization of the network-motifs, '''activity motifs''' are over occurring patterns that can be found when nodes and edges in the network are annotated with quantitative features. For instance, when edges in a metabolic pathways are annotated with the magnitude or timing of the corresponding gene expression, some patterns are over occurring '''given''' the underlying network structure.<ref name="agc">{{cite journal |vauthors=Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D |title=Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network |journal=Nat. Biotechnol. |volume=26 |issue=11 |pages=1251–9 |date=November 2008 |pmid=18953355 |pmc=2651818 |doi=10.1038/nbt.1499}}</ref>
关于网络模体有一个有趣的概括：
在一个对节点（node）和边（edge）以量化标注的网络中，'''活动模体'''是<font color="red">反复</font>的斑图。例如，当新城代谢的边以相应基因的表达量或<font color="red">时间</font>来标注时，一些斑图在'''给定的'''底层网络结构里<font color="red">是反复的</font>。<ref name="agc">{{cite journal |vauthors=Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D |title=Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network |journal=Nat. Biotechnol. |volume=26 |issue=11 |pages=1251–9 |date=November 2008 |pmid=18953355 |pmc=2651818 |doi=10.1038/nbt.1499}}</ref>
==Criticism==
==Criticism==