| As a field of study, particularly, the study of the interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system (for example, the enzymes and metabolites in a metabolic pathway or the heart beats). | | As a field of study, particularly, the study of the interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system (for example, the enzymes and metabolites in a metabolic pathway or the heart beats). |
| As a paradigm, systems biology is usually defined in antithesis to the so-called reductionist paradigm (biological organisation), although it's fully consistent with the scientific method. The distinction between the two paradigms is referred to in these quotations: "The reductionist approach has successfully identified most of the components and many of the interactions but, unfortunately, offers no convincing concepts or methods to understand how system properties emerge ... the pluralism of causes and effects in biological networks is better addressed by observing, through quantitative measures, multiple components simultaneously and by rigorous data integration with mathematical models." (Sauer et al.) "Systems biology ... is about putting together rather than taking apart, integration rather than reduction. It requires that we develop ways of thinking about integration that are as rigorous as our reductionist programmes, but different. ... It means changing our philosophy, in the full sense of the term." (Denis Noble) | | As a paradigm, systems biology is usually defined in antithesis to the so-called reductionist paradigm (biological organisation), although it's fully consistent with the scientific method. The distinction between the two paradigms is referred to in these quotations: "The reductionist approach has successfully identified most of the components and many of the interactions but, unfortunately, offers no convincing concepts or methods to understand how system properties emerge ... the pluralism of causes and effects in biological networks is better addressed by observing, through quantitative measures, multiple components simultaneously and by rigorous data integration with mathematical models." (Sauer et al.) "Systems biology ... is about putting together rather than taking apart, integration rather than reduction. It requires that we develop ways of thinking about integration that are as rigorous as our reductionist programmes, but different. ... It means changing our philosophy, in the full sense of the term." (Denis Noble) |
− | 作为一种范式,系统生物学通常被定义为与所谓的还原论范式(生物组织)相对立的,尽管它完全符合科学方法。引文中提到了两种范式之间的区别: ”简化论的方法成功地确定了大多数组成部分和许多相互作用,但不幸的是,没有提供令人信服的概念或方法来理解系统特性是如何出现的... 生物网络中因果关系的多元性最好通过观察,通过定量措施,多个组成部分同时进行,以及通过与数学模型进行严格的数据整合来解决(Sauer 等人)“系统生物学... ... 是关于整合而不是分解,是关于整合而不是简化。它要求我们发展出与我们的简化论方案一样严谨但不同的整合思维方式。 ..。这意味着彻底改变我们的哲学。”(丹尼斯 · 诺贝尔)
| + | 作为一种研究范式,系统生物学通常被认为与所谓的还原论范式(生物组织)相对立,尽管它完全符合科学方法。这些语录中提到了两种范式之间的区别: “还原论方法成功地确定了大多数组成部分和许多相互作用,但不幸的是,没有提供令人信服的概念或方法来理解系统特性是如何出现的... 生物网络中因果关系的多元性最好通过多个组分同时进行定量测量,以及与数学模型进行严格的数据整合来解决。”(Sauer 等人)“系统生物学...是关于合并而不是分解,是关于整合而不是简化。它要求我们发展出与我们的还原论方法一样严谨但不同的整合思维方式...这意味着彻底改变我们的哲学。”(丹尼斯 · 诺贝尔) |